Lin J
Sichuan Institute of Labour Hygiene and Occupational Diseases, Chengdu.
Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Sep;24(5):274-6.
The level of serum angiotensin-I-converting enzyme (SACE) activity on experimental silicosis in rats at different stages and under treatment with PVNO is reported. The results showed that levels of SACE in each dust groups begun to rise significantly higher than control groups as from the fifth day until 180th day (P less than 0.05). The levels of SACE of treatment groups with PVNO were significantly lower than the dust groups and similar to normal groups of the same age. It is suggested that SACE activity might be used as a reference index of silicosis.
本文报道了不同阶段实验性大鼠矽肺以及在用吡嗪酮（PVNO）治疗情况下血清血管紧张素 I 转换酶（SACE）活性水平。结果显示，各粉尘组中 SACE 水平从第 5 天起至第 180 天显著高于对照组（P<0.05）。PVNO 治疗组的 SACE 水平显著低于粉尘组，且与同年龄正常组相近。提示 SACE 活性可作为矽肺的一项参考指标。
