Yu L, Zhou C Q, Li Y R, Qu L, Xing K J, Du Q C
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China.
Biomed Environ Sci. 1995 Sep;8(3):265-8.
A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats.
为了解汉防己甲素-PVNO及汉防己甲素-QOHP联合使用在矽肺治疗中发挥重要作用的治疗效应机制，需要有更深入的了解。测定了用汉防己甲素-PVNO或汉防己甲素-QOHP治疗后的矽肺大鼠的血脯氨酸肽酶（PLD）、单胺氧化酶（MAO）和纤溶酶原（PLG）。将所得值与未治疗的矽肺大鼠进行比较。结果发现，接受汉防己甲素-PVNO治疗的矽肺大鼠的PLD显著升高，PLG降低，但MAO无显著变化。接受汉防己甲素-QOHP治疗的矽肺大鼠血浆中的PLD显著升高，但PLG和MAO变化不明显。这些发现表明，汉防己甲素-PVNO与汉防己甲素-QOHP联合使用可加速矽肺大鼠胶原蛋白的降解。
