Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy.
Mult Scler. 2012 Feb;18(2):229-31. doi: 10.1177/1352458511414965. Epub 2011 Jul 14.
Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). Cortical lesions (CLs), detected by specific MRI sequences, are likely to become a new research outcome in MS studies. The aim of this study was to infer the optimal statistical model describing the distribution of CLs in patients with relapsing-remitting (RR)MS. The negative binomial model gave the best fit to the observed distribution of CLs in a group of 44 RRMS patients with one MRI scan of the brain. This observation has important implications for the statistical analysis of CLs in MS studies.
最近的研究表明，大脑灰质在多发性硬化症（MS）中的参与具有相关性。通过特定的 MRI 序列检测到的皮质病变（CLs）可能成为 MS 研究中的一个新的研究结果。本研究旨在推断描述复发缓解型（RR）MS 患者 CL 分布的最佳统计模型。在对 44 例接受一次脑部 MRI 扫描的 RRMS 患者的 CL 观察分布中，负二项式模型拟合最好。这一观察结果对 MS 研究中 CL 的统计分析具有重要意义。
