From the Department of Anatomy (J.M.), University of Quebec in Trois-Rivieres, Trois-Rivieres, Quebec, Canada
McConnell Brain Imaging Centre (J.M., M.D., D.A.R., D.D.N., C.E., D.L.C., D.L.A., S.N.), Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
AJNR Am J Neuroradiol. 2019 Jul;40(7):1162-1169. doi: 10.3174/ajnr.A6099. Epub 2019 Jun 20.
BACKGROUND AND PURPOSE: Our aims were the following: 1) to compare multicontrast cortical lesion detection using 3T and 7T MR imaging, 2) to compare cortical lesion type frequency in relapsing-remitting and secondary-progressive MS, and 3) to assess whether detectability is related to the magnetization transfer ratio, an imaging marker sensitive to myelin content. MATERIALS AND METHODS: Multicontrast 3T and 7T MR images from 10 participants with relapsing-remitting MS and 10 with secondary-progressive MS. We used the following 3T contrast sequences: 3D-T1-weighted, quantitative T1, FLAIR, magnetization-transfer, and 2D proton-density- and T2-weighted. We used the following 7T contrast sequences: 3D-T1-weighted, quantitative T1, and 2D-T2*-weighted. RESULTS: Cortical lesion counts at 7T were the following: 720 total cortical lesions, 420 leukocortical lesions (58%), 27 intracortical lesions (4%), and 273 subpial lesions (38%). Cortical lesion counts at 3T were the following: 424 total cortical, 393 leukocortical (93%), zero intracortical, and 31 subpial (7%) lesions. Total, intracortical, and subpial 3T lesion counts were significantly lower than the 7T counts ( < .002). Leukocortical lesion counts were not significantly different between scanners. Total and leukocortical lesion counts were significantly higher in secondary-progressive MS, at 3T and 7T ( ≤ .02). Subpial lesions were significantly higher in secondary-progressive MS at 7T ( = .006). The magnetization transfer ratio values of leukocortical lesions visible on both scanners were significantly lower than the magnetization transfer ratio values of leukocortical lesions visible only at 3T. No significant difference was found in magnetization transfer ratio values between subpial lesions visible only at 7T and subpial lesions visible on both 3T and 7T. CONCLUSIONS: Detection of leukocortical lesions at 3T is comparable with that at 7T MR imaging. Imaging at 3T is less sensitive to intracortical and subpial lesions. Leukocortical lesions not visible on 7T T2*-weighted MRI may be associated with less demyelination than those that are visible. Detectability of subpial lesions does not appear to be related to the degree of demyelination.
背景与目的：我们的目的如下：1）比较使用 3T 和 7T 磁共振成像检测皮质病变的效果，2）比较复发缓解型和继发进展型多发性硬化症患者皮质病变类型的频率，以及 3）评估检测效果是否与磁化传递率（一种对髓鞘含量敏感的成像标志物）相关。 材料与方法：本研究纳入 10 例复发缓解型和 10 例继发进展型多发性硬化症患者，使用多对比度 3T 和 7T 磁共振成像。我们使用了以下 3T 对比序列：3D-T1 加权、定量 T1、FLAIR、磁化传递以及 2D 质子密度加权和 T2 加权。我们使用了以下 7T 对比序列：3D-T1 加权、定量 T1 和 2D-T2加权。 结果：7T 皮质病变计数如下：总皮质病变 720 个，白质皮质病变 420 个（58%），皮质内病变 27 个（4%），皮质下病变 273 个（38%）。3T 的皮质病变计数如下：总皮质病变 424 个，白质皮质病变 393 个（93%），皮质内病变 0 个，皮质下病变 31 个（7%）。皮质内和皮质下病变计数在 3T 和 7T 之间差异均有统计学意义（<0.002）。皮质下病变计数在两种扫描仪之间无显著差异。3T 和 7T 下，继发进展型 MS 的总皮质病变、皮质内病变和皮质下病变计数均显著高于复发缓解型 MS（≤0.02）。7T 下，继发进展型 MS 的皮质下病变显著高于复发缓解型 MS（=0.006）。两种扫描仪均可显示的白质皮质病变的磁化传递率明显低于仅在 3T 上可见的白质皮质病变的磁化传递率。仅在 7T 上可见的皮质下病变与两种扫描仪上均可见的皮质下病变的磁化传递率之间无显著差异。 结论：3T 上白质皮质病变的检出与 7T 磁共振成像相当。3T 成像对皮质内和皮质下病变的敏感性较低。7T T2加权 MRI 上不可见的白质皮质病变可能与可见的白质皮质病变相比脱髓鞘程度较轻。皮质下病变的可检测性似乎与脱髓鞘程度无关。
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