Götze W, Jantschak J, Kohls A, Elling D, Schildhaus I
Klinik für Gynäkologie und Geburtshilfe, Bereichs Medizin (Charité) der Humboldt-Universität zu Berlin.
Zentralbl Gynakol. 1990;112(14):875-81.
280 women have been tested by FISH to detect an HPV 16/18-infection of the portio uteri. In a group of 133 women treated by conisation (all with a history of abnormal smear and colposcopy) 67 (50%) were positive for HPV 16/18 DNA before the operation. Follow up examinations of 20 cases with positive HPV 16/18 test before conisation, showed 6 and 12 months after operation only in 3 cases a persistence of HPV 16/18 infection. Only 5 (6.4%) of 78 women with a history of conisation and diagnosis CIN III some years ago were positive for HPV 16/18. In another group of 47 elderly women, treated by abrasio and with normal cervical histology, only 5 (10.6%) had a positive result in the HPV 16/18 FISH-test. 2 (10.6%) of 22 women with normal smear and colposcopy (control group) were positive for HPV 16/18.
280名女性接受了荧光原位杂交（FISH）检测，以检测子宫颈HPV 16/18感染情况。在一组133名接受锥切术治疗的女性中（所有患者均有涂片异常和阴道镜检查史），67名（50%）在手术前HPV 16/18 DNA检测呈阳性。对锥切术前HPV 16/18检测呈阳性的20例患者进行随访检查，术后6个月和12个月时仅3例持续存在HPV 16/18感染。在78名几年前有锥切术史且诊断为CIN III的女性中，只有5名（6.4%）HPV 16/18检测呈阳性。在另一组47名接受宫颈刮除术且宫颈组织学正常的老年女性中，只有5名（10.6%）HPV 16/18 FISH检测结果为阳性。在22名涂片和阴道镜检查正常的女性（对照组）中，2名（10.6%）HPV 16/18检测呈阳性。
