Göppinger A, Ikenberg H, Birmelin G, Hilgarth M, Pfleiderer A, Hillemanns H G
Universitäts-Frauenklinik Freiburg i Br.
Geburtshilfe Frauenheilkd. 1988 May;48(5):343-5. doi: 10.1055/s-2008-1035988.
In 104 woman patients with cervical intraepithelial neoplasia (CIN) I-III who had been treated between 1981 and May 1986 in the dysplasia consulting-room of the Department of Gynecology by means of conisation effected by laser, we checked on therapeutic success via cytology and colposcopy as well as by human papilloma virus (HPV) typing. In 90.3% of the cases 1.25 laser treatments sufficed for healing of the lesion. Relapses occurred mainly in severe intraepithelial neoplasias with identified HPV 16/18. Incidence of HPV was reduced from 56% before therapy to 13.3% after therapy. This shows that laser therapy can be regarded as an effective treatment of the causes of the disease even in CIN associated with HPV. The markedly increased relapse rate in CIN III (24%) makes a reliable follow-up mandatory especially in such cases.
1981年至1986年5月期间，在妇科发育异常咨询室，对104例宫颈上皮内瘤变（CIN）I - III级的女性患者采用激光锥切术进行治疗。我们通过细胞学、阴道镜检查以及人乳头瘤病毒（HPV）分型来检查治疗效果。在90.3%的病例中，1.25次激光治疗足以使病变愈合。复发主要发生在确诊为HPV 16/18的重度上皮内瘤变中。HPV的发生率从治疗前的56%降至治疗后的13.3%。这表明，即使在与HPV相关的CIN中，激光治疗也可被视为一种有效的病因治疗方法。CIN III级中显著升高的复发率（24%）使得可靠的随访成为必要，尤其是在这类病例中。
