Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA.
Nat Rev Immunol. 2011 Jul 15;11(8):532-43. doi: 10.1038/nri3014.
Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines.
登革热是一种蚊媒病毒性疾病，其地理范围和发病率不断扩大。四种病毒血清型的存在以及既往登革病毒感染与更严重疾病风险增加之间的关联，给疫苗开发带来了重大障碍。对自然感染登革病毒的适应性免疫反应以及候选登革热疫苗的进一步了解，有助于确定与登革热感染期间保护性或病理性免疫相关的特定抗体和 T 细胞反应。进一步描述疾病结局的免疫学相关性，并在疫苗试验中验证这些发现，对于开发有效的登革热疫苗将是非常宝贵的。
