Research Center for Skin Diseases and Cutaneous Leishmaniasis, Ghaem Hospital.
Clin Cosmet Investig Dermatol. 2011;4:69-72. doi: 10.2147/CCID.S20531. Epub 2011 Jun 2.
Hirsutism is a common problem in dermatology that imposes high socioeconomical costs on medical care. Consequently, researchers are actively searching for cheaper and safer methods for therapeutic treatment. The objective of the present study is to evaluate formic oil, enriched from formic acid, for the removal of unwanted hair. In this study, 32 female rats (150-200 g) were randomly divided into four groups and maintained with normal water and food availability. A patch of skin was shaved on each rat for application of test solutions. The control group was treated with local once-daily applications of normal saline. The formic acid, acetic acid, and sodium formate groups were treated with once-daily applications of formic acid (pH 5.5), acetic acid (pH 5.5), or sodium formate, respectively. After 2 weeks, horizontally cut sample biopsies were removed, and the numbers of hair follicles were counted under high field microscopy by a specialist blinded to the treatments. Kolmogorov-Smirnov test results indicated a nonparametric distribution for the rat groups. ANOVA analysis indicated no statistically significant differences between groups (P < 0.05). There weren't any side effects or evidence for toxicity during the study period. However, hair follicle counts showed a descending order of control, acetic acid, formic acid, and sodium formate. Although the sodium formate group had the lowest hair follicle numbers, the difference was not statistically significant (P > 0.05). Formic acid was not effective in reducing hair follicle numbers in rats.
多毛症是皮肤科的常见问题，给医疗保健带来了高昂的社会经济成本。因此，研究人员正在积极寻找更便宜、更安全的治疗方法。本研究旨在评估甲酸油（甲酸富化而成）去除多余毛发的效果。在这项研究中，将 32 只雌性大鼠（150-200g）随机分为四组，给予正常水和食物供应。在每只大鼠的皮肤上剃下一块皮肤，用于涂抹测试溶液。对照组用局部生理盐水每日一次处理。甲酸组、乙酸组和甲酸钠组分别用 pH5.5 的甲酸、乙酸和甲酸钠每日一次处理。2 周后，取下水平切口的活检样本，由对处理方法不知情的专家在高倍显微镜下计数毛囊数量。Kolmogorov-Smirnov 检验结果表明大鼠组呈非参数分布。方差分析表明各组之间无统计学差异（P＜0.05）。研究期间没有任何副作用或毒性证据。然而，毛囊计数显示出对照组、乙酸组、甲酸组和甲酸钠组依次下降的趋势。尽管甲酸钠组的毛囊数量最少，但差异无统计学意义（P＞0.05）。甲酸对减少大鼠毛囊数量没有效果。
