壳聚糖-十二烷基硫酸钠纳米粒作为口服胰岛素体内传递的载体系统。
Chitosan-sodium lauryl sulfate nanoparticles as a carrier system for the in vivo delivery of oral insulin.
机构信息
Department of Pharmaceutics, Faculty of Pharmacy, Gezira University, Medani, Sudan.
出版信息
AAPS PharmSciTech. 2011 Sep;12(3):958-64. doi: 10.1208/s12249-011-9647-5. Epub 2011 Jul 15.
Abstract
The present work explores the possibility of formulating an oral insulin delivery system using nanoparticulate complexes made from the interaction between biodegradable, natural polymer called chitosan and anionic surfactant called sodium lauryl sulfate (SLS). The interaction between chitosan and SLS was confirmed by Fourier transform infrared spectroscopy. The nanoparticles were prepared by simple gelation method under aqueous-based conditions. The nanoparticles were stable in simulated gastric fluids and could protect the encapsulated insulin from the GIT enzymes. Additionally, the in vivo results clearly indicated that the insulin-loaded nanoparticles could effectively reduce the blood glucose level in a diabetic rat model. However, additional formulation modifications are required to improve insulin oral bioavailability.
摘要
本研究探索了使用由生物可降解天然聚合物壳聚糖与阴离子表面活性剂月桂基硫酸钠（SLS）相互作用形成的纳米颗粒复合物来制备口服胰岛素递药系统的可能性。傅里叶变换红外光谱证实了壳聚糖和 SLS 之间的相互作用。纳米颗粒是通过简单的凝胶化方法在水基条件下制备的。纳米颗粒在模拟胃液中稳定，可以保护包封的胰岛素免受胃肠道酶的影响。此外，体内结果清楚地表明，载胰岛素纳米颗粒可以有效地降低糖尿病大鼠模型的血糖水平。然而，需要进一步的制剂修改来提高胰岛素的口服生物利用度。
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本文引用的文献
1
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2
[Analysis of issues of insulin self-injection in elderly].[老年患者胰岛素自我注射问题分析]
Nihon Ronen Igakkai Zasshi. 2009;46(6):537-40. doi: 10.3143/geriatrics.46.537.
3
Barriers to insulin injection therapy: patient and health care provider perspectives.胰岛素注射治疗的障碍：患者和医疗保健提供者的观点。
Diabetes Educ. 2009 Nov-Dec;35(6):1014-22. doi: 10.1177/0145721709345773.
4
Alternative routes of insulin delivery.胰岛素递送的替代途径。
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Oct;34(10):933-48.
5
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Eur J Pharm Biopharm. 2009 Oct;73(2):269-79. doi: 10.1016/j.ejpb.2009.06.004. Epub 2009 Jun 7.
6
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J Control Release. 2009 Apr 17;135(2):144-51. doi: 10.1016/j.jconrel.2009.01.011.
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Neuro Endocrinol Lett. 2009 Mar;30(1):74-8.
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J Nanosci Nanotechnol. 2007 Aug;7(8):2833-41. doi: 10.1166/jnn.2007.609.
10
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