Krishnankutty Ranjith K, Mathew Aju, Sedimbi Saikiran K, Suryanarayan Shrikumar, Sanjeevi Carani B
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Oct;34(10):933-48.
Parenteral route of insulin administration has been the mode of treatment for all Type 1 diabetics and Type 2 diabetics with complications. Patient compliance has really been a major concern for this route of administration. Several alternative routes of administration are under consideration for effective glycemic control, including oral, inhaled, buccal, nasal, and patch routes. One of the approaches involving inhaled insulin has now reached the market. Several other candidates may reach the market in the near future, the promising one being oral insulin.
胰岛素的肠胃外给药途径一直是所有1型糖尿病患者和有并发症的2型糖尿病患者的治疗方式。患者的依从性一直是这种给药途径的一个主要问题。为了有效控制血糖，正在考虑几种替代给药途径，包括口服、吸入、颊部、鼻腔和贴片途径。其中一种涉及吸入式胰岛素的方法现已上市。其他几种候选方法可能在不久的将来上市，最有前景的是口服胰岛素。
