Gillissen A
Klinik für Lungen- und Bronchialmedizin, Klinikum Kassel.
Pneumologie. 2011 Sep;65(9):549-57. doi: 10.1055/s-0030-1256592. Epub 2011 Jul 14.
N-acetylcyteine (NAC) is a thiol containing compound which by providing Sulfhydryl groups, can act both as a precursor or reduced glutathione and as a direct scavenger of reactive oxygen species. By regulation the redox status in cells, it can interfere with several signaling pathways that play a role in regulation apoptosis, angiogenesis, cell growth, nuclear transcription and cytokine production. In humans NAC had been proven to improve idiopathic pulmonary fibrosis (IPF), various forms of alveolitis and to avoid hepatoxic effects of paracetamol and paraquate through binding these compounds enabling biliary excretion. Overall, the anti-inflammatory action of NAC is well documented in vitro as well as in vivo. This review summarizes the biochemical effects of NAC and hints proven and likely diseases where NAC have or might have a beneficial effect.
N-乙酰半胱氨酸（NAC）是一种含硫醇的化合物，它通过提供巯基，既可以作为还原型谷胱甘肽的前体，又可以作为活性氧的直接清除剂。通过调节细胞内的氧化还原状态，它可以干扰多种在细胞凋亡、血管生成、细胞生长、核转录和细胞因子产生的调节中起作用的信号通路。在人类中，已证实NAC可改善特发性肺纤维化（IPF）、各种形式的肺泡炎，并通过结合对乙酰氨基酚和百草枯使其经胆汁排泄，从而避免其肝毒性作用。总体而言，NAC的抗炎作用在体外和体内均有充分记录。本综述总结了NAC的生化作用，并提示了已证实的以及可能对NAC有有益作用的疾病。
