Orozco-Levi Mauricio, Colmenares-Mejía Claudia, Ruíz Jessica, Valencia-Barón Yurley Dayanna, Ramírez-Sarmiento Alba, Quintero-Lesmes Doris Cristina, Serrano Norma C
Servicio de Neumología, Fundación Cardiovascular de Colombia, Hospital Internacional de Colombia, Calle 155A No. 23-58 Floridablanca Santander/Valle de Menzuly Km 7 Piedecuesta, Santander, Colombia.
Centro de Investigaciones Fundación Cardiovascular de Colombia, Calle 155A No. 23-58 Floridablanca, Santander, Colombia.
J Nutr Metab. 2021 Nov 24;2021:7463391. doi: 10.1155/2021/7463391. eCollection 2021.
Chronic obstructive pulmonary disease (COPD) is a common, preventable, treatable lung disease characterized by persistent respiratory symptoms and airflow limitation and multiorgan impact. This affects the nutritional status of patients and requires multidimensional interventions including nutritional interventions according to individual metabolic needs. Our scoping review determined the effects of antioxidants in the treatment of COPD patients and their role in the decrease in the probability of exacerbations, hospital readmissions, and changes in lung function. The sources MEDLINE, LILACS, and Google Scholar were consulted and 19 studies were selected. The most indicated antioxidants are N-Acetylcysteine, vitamins E and D, and Zinc. Other antioxidants from plants or fruits extracts are also being investigated. The beneficial effect of antioxidants in stable or exacerbated patients is not clear, but theoretical and biological arguments of benefit justify lines of research that specify the impact on reducing oxidative stress and negative effects in COPD.
慢性阻塞性肺疾病（COPD）是一种常见的、可预防、可治疗的肺部疾病，其特征为持续的呼吸道症状、气流受限以及多器官影响。这会影响患者的营养状况，需要进行多维度干预，包括根据个体代谢需求进行营养干预。我们的范围综述确定了抗氧化剂在治疗COPD患者中的作用及其在降低急性加重、再次入院概率和肺功能变化方面的作用。查阅了MEDLINE、LILACS和谷歌学术等资源，并选择了19项研究。最常用的抗氧化剂是N-乙酰半胱氨酸、维生素E和D以及锌。来自植物或水果提取物的其他抗氧化剂也在研究中。抗氧化剂对稳定期或急性加重期患者的有益作用尚不清楚，但有益的理论和生物学依据证明了进一步研究的合理性，这些研究旨在明确其对降低COPD氧化应激和负面影响的作用。
