第七版 AJCC 胃癌分期修改的验证。
Validation of seventh edition AJCC gastric cancer staging modifications.
机构信息
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
J Surg Oncol. 2012 Jan;105(1):26-30. doi: 10.1002/jso.22026. Epub 2011 Jul 14.
BACKGROUND AND OBJECTIVES
The seventh edition of the AJCC has more detailed staging categories for gastric cancer than does the sixth edition. The aim of our study was to compare the prognostic accuracies of the sixth and seventh AJCC editions for gastric cancer patients.
METHODS
We analyzed survival rates by category using the sixth and seventh editions of the AJCC in 10,060 patients with gastric cancer who had undergone gastrectomy between 1994 and 2007 at Samsung Medical Center.
RESULTS
Significant differences in prognosis were seen when comparing the new stages of the seventh edition of the AJCC that are subgroups of stages IB, II, IIIA, and IV in the sixth edition. In particular, stage IV of the AJCC sixth edition is divided into stages IIB, IIIA, IIIB, IIIC and IV in the seventh edition, and the 5-year survival rates of these respective stages were 80.2%, 45.3%, 23.5%, 17.2%, and 10.1% (P < 0.001).
CONCLUSIONS
Each category of the AJCC sixth edition has been divided into multiple stages in the AJCC seventh edition, each with a different prognosis. The newly divided subgroups from AJCC sixth edition stage IV showed more accurate outcome classification based on AJCC seventh edition staging stratification.
背景与目的
第七版 AJCC 对胃癌的分期分类比第六版更为详细。本研究旨在比较第六版和第七版 AJCC 对胃癌患者的预后准确性。
方法
我们分析了 1994 年至 2007 年间在三星医疗中心接受胃切除术的 10060 例胃癌患者的生存率，使用第六版和第七版 AJCC 进行分类。
结果
与第六版 AJCC 的新分期相比，第七版 AJCC 的 IB、II、IIIA 和 IV 期的亚组分期存在显著的预后差异。特别是第六版 AJCC 的 IV 期在第七版 AJCC 中被分为 IIB、IIIA、IIIB、IIIC 和 IV 期，这些分期的 5 年生存率分别为 80.2%、45.3%、23.5%、17.2%和 10.1%（P<0.001）。
结论
第六版 AJCC 的每个类别在第七版 AJCC 中都被细分为多个分期，每个分期的预后都不同。第六版 AJCC 的 IV 期新分组根据第七版 AJCC 分期分层显示出更准确的预后分类。
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