Czermak M, Jean T
Psychiatre des Hôpitaux, Hôpital Henri Rousselle, Paris.
Encephale. 1990 Sep-Oct;16(5):375-82.
The AIDS epidemic is currently considered to be the first retroviral disease in humans. However, in the large volume of work on von Economo-Cruchet's encephalitis lethargica, the authors reveal a series of common points between both diseases. The progress of both diseases is identical at every stage, with neurotropism, premature psychological disorders, mononucleasic syndrome, similar somatic manifestations of the viral attack and terminal dementia. The anatomo-pathological and epidemiological data, along with the hypothesis that encephalitis lethargica is sexually transmitted, reinforce the idea of a relationship between the two diseases. The interest which would be aroused by the discovery of a viral origin of encephalitis lethargica and the resulting experimental elements seem to make it worthwhile leaving the question open in order to find a precise answer. We are calling on all our colleagues in basic research to seek a solution to what we think is an essential question.
目前，艾滋病疫情被认为是人类的首例逆转录病毒疾病。然而，在大量关于冯·埃科诺莫-克鲁谢特昏睡性脑炎的研究工作中，作者揭示了这两种疾病之间的一系列共同点。两种疾病在每个阶段的进展都是相同的，具有嗜神经性、过早出现的心理障碍、单核细胞增多综合征、病毒攻击的类似躯体表现以及晚期痴呆。解剖病理学和流行病学数据，以及昏睡性脑炎是性传播疾病的假说，强化了这两种疾病之间存在关联的观点。发现昏睡性脑炎的病毒起源以及由此产生的实验证据所引发的兴趣，似乎使得值得暂时搁置这个问题，以便找到一个确切的答案。我们呼吁所有基础研究领域的同事寻求解决我们认为这一至关重要问题的办法。
