Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA.
Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8051-6. doi: 10.1002/anie.201101817. Epub 2011 Jul 14.
Raising the bar: the efficacy of bioorthogonal reactions for bioconjugation has been thoroughly evaluated in four different biological settings. Powered by the development of new biocompatible ligands, the copper-catalyzed azide-alkyne cycloaddition has brought about unsurpassed bioconjugation efficiency, and thus it holds great promise as a highly potent and adaptive tool for a broader spectrum of biological applications.
生物正交反应在四种不同的生物学环境中的生物缀合功效已经得到了彻底的评估。新型生物相容性配体的发展推动了铜催化的叠氮-炔环加成反应，带来了前所未有的生物缀合效率，因此它有望成为更广泛的生物学应用的一种高效、适应性强的工具。
