Henne-Bruns D, Kreischer H P, Schmiegelow P, Kremer B
Department of Surgery, University of Hamburg, FRG.
Eur Surg Res. 1990;22(4):224-30. doi: 10.1159/000129105.
Polyglycolic acid (PGA) meshes have successfully been used in the treatment of injured parenchymatous organs. In our study we investigated the value of PGA meshes for reinforcement of colon anastomoses in a rat model. In 75 Wistar rats the transverse colon was transected and reanastomosed in a single-layer technique. The anastomoses in half of the animals were performed with 6 stitches. In the other animals the anastomoses were performed with 4 stitches only and were therefore supposed to leak. In half of the animals of each group a PGA mesh was used to cover the anastomoses. Animals of each group were sacrificed after 2, 4, 8, 30 and 60 days. The bursting strength of the anastomoses was determined and the anastomosed region was examined histologically. The results demonstrate that regardless of how the anastomosis was applied motility disorders, delayed healing or leakage followed by peritonitis only occurred in animals in which a PGA mesh was used. The determination of the bursting strength also showed a marked decrease in all rats in which the anastomosis was reinforced with a PGA mesh. We therefore conclude that PGA mesh application in colon anastomoses results in impaired healing, which is probably due to reduced peritoneal or omental contact.
聚乙醇酸（PGA）网片已成功用于治疗实质器官损伤。在我们的研究中，我们在大鼠模型中研究了PGA网片对结肠吻合口加固的价值。在75只Wistar大鼠中，横结肠被切断并采用单层技术进行重新吻合。一半动物的吻合口用6针缝合。另一半动物的吻合口仅用4针缝合，因此预计会发生渗漏。每组动物中的一半使用PGA网片覆盖吻合口。每组动物在术后2、4、8、30和60天处死。测定吻合口的破裂强度，并对吻合区域进行组织学检查。结果表明，无论吻合口如何处理，运动障碍、愈合延迟或渗漏伴发腹膜炎仅发生在用PGA网片的动物中。破裂强度的测定还显示，所有用PGA网片加固吻合口的大鼠其破裂强度均显著降低。因此，我们得出结论，在结肠吻合术中应用PGA网片会导致愈合受损，这可能是由于腹膜或网膜接触减少所致。
