Kiyosawa K, Tanaka E, Sodeyama T, Furuta K, Usuda S, Yousuf M, Furuta S
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.
Jpn J Cancer Res. 1990 Nov;81(11):1089-91. doi: 10.1111/j.1349-7006.1990.tb02517.x.
Fifty-eight patients with chronic hepatitis C were followed for more than 7 years. Of them, 10 patients were found to develop hepatocellular carcinoma, 14 to develop liver cirrhosis, 30 to sustain chronic hepatitis, and 4 to show subsidence of hepatitis. Antibody to hepatitis C virus (anti-HCV) disappeared from the 4 patients whose hepatitis subsided, but it persisted in the remaining 54 patients. The mean titer of anti-HCV was almost the same at the stages of chronic hepatitis and of cancer in the 10 patients who developed hepatocellular carcinoma. These results indicate that chronic infection of hepatitis C virus may lead to hepatocellular carcinoma.
58例慢性丙型肝炎患者随访超过7年。其中，10例患者发生肝细胞癌，14例发展为肝硬化，30例维持慢性肝炎，4例肝炎症状缓解。肝炎症状缓解的4例患者体内丙型肝炎病毒抗体（抗-HCV）消失，但其余54例患者体内该抗体持续存在。在发生肝细胞癌的10例患者中，慢性肝炎阶段和癌症阶段的抗-HCV平均滴度几乎相同。这些结果表明，丙型肝炎病毒的慢性感染可能导致肝细胞癌。
