Bello Olalla, Fernandez-Del-Olmo Miguel
Learning and Human Movement Control Group, INEF Galicia, University of A Coruña, Spain.
Curr Aging Sci. 2012 Feb;5(1):28-34. doi: 10.2174/1874609811205010028.
Parkinson's disease (PD) is clinically characterized by symptoms of akinesia, rigidity, and resting tremor, which are related to a dopaminergic deficiency of the nigrostriatal pathway. Disorders of gait are common symptoms of PD that affect the quality of life in these patients. One of the main focuses of physical rehabilitation in PD is to improve the gait deficits in the patients. In the last decade, a small number of studies have investigated the use of the treadmill for the rehabilitation of gait in PD patients. Although, the results of these studies are promising, the mechanisms underlying the therapeutic effect of the treadmill in PD are still largely unknown. This paper reviews 10 years of investigation of treadmill training in PD, focusing on the possible mechanisms involved in the therapeutic effect of the treadmill. Understanding these mechanisms may improve the prescription and design of physical therapy programs for PD patients.
帕金森病（PD）的临床特征为运动不能、僵硬和静止性震颤等症状，这些症状与黑质纹状体通路的多巴胺能缺乏有关。步态障碍是PD的常见症状，会影响这些患者的生活质量。PD物理康复的主要重点之一是改善患者的步态缺陷。在过去十年中，少数研究调查了使用跑步机对PD患者进行步态康复的情况。尽管这些研究结果很有前景，但跑步机对PD治疗作用的潜在机制仍 largely unknown。本文回顾了对PD患者进行跑步机训练的十年研究，重点关注跑步机治疗作用可能涉及的机制。了解这些机制可能会改善针对PD患者的物理治疗方案的处方和设计。
