Department of Psychiatry and Psychotherapy, University of Cologne, Germany.
Addict Biol. 2011 Oct;16(4):620-3. doi: 10.1111/j.1369-1600.2011.00337.x. Epub 2011 Jul 18.
Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error-related negativity) linked to anterior mid-cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.
近年来，神经调节疗法在精神障碍治疗方面取得了新进展，我们对一名重度酒精成瘾患者进行了伏隔核（NAc）深部脑刺激（DBS）治疗。在手术前后一年，我们评估了 DBS 对成瘾、心理测量评分和认知控制的电生理测量的影响。在我们的患者中，DBS 实现了成瘾行为和渴望的正常化。与前扣带皮层（aMCC）功能相关的错误处理的电生理标记（错误相关负波）通过 DBS 发生改变，这种影响可以通过不刺激期来逆转。因此，该病例支持这样的假设，即 NAc 的 DBS 通过与 aMCC 功能障碍相关的渴望的正常化，可能对成瘾产生积极影响。
