Clinic and Polyclinic for Dermatology, Venereology, and Allergology, Essen University Hospital, Hufelandstrasse 55, Essen, Germany.
J Dtsch Dermatol Ges. 2012 Apr;10(4):251-7. doi: 10.1111/j.1610-0387.2011.07734.x. Epub 2011 Jul 15.
Pyoderma gangrenosum is a rare, destructive, ulcerative neutrophilic dermatosis of unknown origin that has been investigated insufficiently in clinical studies. According to current textbooks, it is often associated with chronic inflammatory bowel diseases or other autoimmune disorders.
We retrospectively analyzed data from 49 patients with pyoderma gangrenosum.
Our results showed that although only 6.1 % of patients had chronic inflammatory bowel disease, 22.4 % patients had a malignancy, 18.4 % had chronic renal insufficiency, and 42.8 % had anemia. A potentially relevant aspect that has received little attention is an association with endocrine diseases in 38.8 % of patients. 28.6 % of patients had diabetes. Given that 32.6 % of patients were obese, a potential association with metabolic syndrome may be considered as a possible new risk factor for pyoderma gangrenosum.
The clinical data from the present study are insufficient for drawing any firm conclusions. We did, however, observe an association between pyoderma gangrenosum and certain as yet unreported co-factors, in particular metabolic syndrome. This should be considered in further studies.
坏疽性脓皮病是一种罕见的、破坏性的、病因不明的中性粒细胞性皮肤病，在临床研究中研究不足。根据目前的教科书，它通常与慢性炎症性肠病或其他自身免疫性疾病有关。
我们回顾性分析了 49 例坏疽性脓皮病患者的数据。
我们的结果表明，尽管只有 6.1%的患者患有慢性炎症性肠病，但 22.4%的患者患有恶性肿瘤，18.4%的患者患有慢性肾功能不全，42.8%的患者患有贫血。一个潜在的相关方面是，内分泌疾病在 38.8%的患者中存在关联。28.6%的患者患有糖尿病。鉴于 32.6%的患者肥胖，代谢综合征可能被认为是坏疽性脓皮病的一个新的潜在危险因素。
本研究的临床数据不足以得出任何明确的结论。然而，我们确实观察到坏疽性脓皮病与某些尚未报道的伴随因素之间存在关联，特别是代谢综合征。这在进一步的研究中应予以考虑。
