Department of Dermatology, Venereology and Allergology, University School of Medicine Essen-Duisburg, Hufelandstrasse 55, Essen 45122, Germany.
Orphanet J Rare Dis. 2013 Sep 8;8:136. doi: 10.1186/1750-1172-8-136.
Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.
Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.
We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.
Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.
坏疽性脓皮病（PG）是一种罕见的、病因不明的溃疡性中性粒细胞皮肤病，迄今为止，在临床研究中对其特征的描述还很不完善。因此，人们对其相关因素和合并症进行了大量讨论。我们的多中心研究旨在分析德国皮肤科伤口护理中心患者的现有数据，以便描述 PG 患者的相关因素和合并症。
对德国皮肤科伤口护理中心的 PG 患者进行回顾性临床调查。
我们收到了来自德国 20 家不同皮肤科伤口护理中心的 259 名 PG 患者的数据。其中 142 名（54.8%）为女性，117 名（45.2%）为男性；年龄在 21 至 95 岁之间，平均年龄为 58 岁。在我们的患者群体中，我们发现 45.6%有贫血，44.8%有内分泌疾病，12.4%有内部恶性肿瘤，9.3%有慢性炎症性肠病，4.3%有肌酐水平升高。此外，25.5%的患者患有糖尿病，其中一些方面可能与代谢综合征有关。
我们的研究描述了世界上最大的 PG 患者群体之一。除了与慢性肠道疾病和肿瘤的已知关联外，一个潜在的相关新方面是与内分泌疾病的关联，特别是代谢综合征、甲状腺功能障碍和肾脏疾病。我们的发现代表了具有临床意义的新方面。这有助于描述患者的特征，并帮助理解这些经常被误诊的患者的潜在病理生理学。
