Monash Immunology and Stem Cell Laboratories (MISCL), Monash University, Melbourne, Australia.
Am J Pathol. 2011 Sep;179(3):1243-56. doi: 10.1016/j.ajpath.2011.05.037. Epub 2011 Jul 14.
Colony-stimulating factor (CSF)-1 controls the survival, proliferation, and differentiation of macrophages, which are recognized as scavengers and agents of the innate and the acquired immune systems. Because of their plasticity, macrophages are endowed with many other essential roles during development and tissue homeostasis. We present evidence that CSF-1 plays an important trophic role in postnatal organ growth and kidney repair. Notably, the injection of CSF-1 postnatally enhanced kidney weight and volume and was associated with increased numbers of tissue macrophages. Moreover, CSF-1 promotes postnatal renal repair in mice after ischemia-reperfusion injury by recruiting and influencing macrophages toward a reparative state. CSF-1 treatment rapidly accelerated renal repair with tubular epithelial cell replacement, attenuation of interstitial fibrosis, and functional recovery. Analysis of macrophages from CSF-1-treated kidneys showed increased expression of insulin-like growth factor-1 and anti-inflammatory genes that are known CSF-1 targets. Taken together, these data suggest that CSF-1 is important in kidney growth and the promotion of endogenous repair and resolution of inflammatory injury.
集落刺激因子（CSF-1）控制巨噬细胞的存活、增殖和分化，巨噬细胞被认为是先天和获得性免疫系统的清道夫和效应细胞。由于其可塑性，巨噬细胞在发育和组织稳态中具有许多其他重要作用。我们提供的证据表明，CSF-1 在出生后器官生长和肾脏修复中发挥重要的营养作用。值得注意的是，CSF-1 在出生后注射可增强肾脏重量和体积，并与组织巨噬细胞数量增加有关。此外，CSF-1 通过招募和影响巨噬细胞向修复状态促进缺血再灌注损伤后的出生后肾脏修复。CSF-1 治疗可迅速加速肾脏修复，包括肾小管上皮细胞替代、间质纤维化减轻和功能恢复。对 CSF-1 治疗肾脏中的巨噬细胞进行分析显示，胰岛素样生长因子-1 和抗炎基因的表达增加，这些基因是 CSF-1 的已知靶标。总之，这些数据表明 CSF-1 在肾脏生长以及促进内源性修复和炎症损伤消退方面具有重要作用。
