Ricardo Sharon D, van Goor Harry, Eddy Allison A
Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia.
J Clin Invest. 2008 Nov;118(11):3522-30. doi: 10.1172/JCI36150.
Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease in the context of fibrosis. Furthermore, parallels with pathological processes in many other organs also exist.
单核细胞衍生的巨噬细胞能够决定免疫反应的结果，以及这种反应是有助于组织修复还是介导组织破坏。除了在免疫介导的肾脏疾病和宿主防御中发挥重要作用外，巨噬细胞在胚胎发育、后天性肾脏疾病和肾移植反应期间的组织重塑中也发挥着重要作用。本综述总结了巨噬细胞在肾脏损伤修复和损伤后特殊肾细胞替代过程中的表型和功能。我们对巨噬细胞在响应其微环境时的异质性的最新认识进展，为在纤维化背景下减轻或可能逆转进行性肾脏疾病带来了新的、令人兴奋的治疗可能性。此外，与许多其他器官的病理过程也存在相似之处。
