内源性 DNA 导致的自身炎症。

Autoinflammation by endogenous DNA.

机构信息

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo, Kyoto, Japan.

出版信息

Adv Immunol. 2011;110:139-61. doi: 10.1016/B978-0-12-387663-8.00004-1.

Abstract

In various mammalian developmental processes such as programmed cell death, erythropoiesis, and lens-cell differentiation, chromosomal DNA is degraded into nucleotides by a set of specific nucleases. If this process does not proceed smoothly, the undigested DNA causes various problems. For example, when chromosomal DNA is not degraded in the lens cells, cataracts form. In other cases, undigested DNA in macrophages activates the innate immune system, like a DNA virus, and causes strong inflammation, resulting in anemia, arthritis, and lymphopenia. Here, we discuss when, where, and how DNA is degraded to maintain mammalian homeostasis.

摘要

在各种哺乳动物的发育过程中，如程序性细胞死亡、红细胞生成和晶状体细胞分化，染色体 DNA 被一组特定的核酸酶降解为核苷酸。如果这个过程不顺利，未被消化的 DNA 会导致各种问题。例如，当晶状体细胞中的染色体 DNA 未被降解时，就会形成白内障。在其他情况下，巨噬细胞中未被消化的 DNA 会像 DNA 病毒一样激活先天免疫系统，引起强烈的炎症，导致贫血、关节炎和淋巴细胞减少症。在这里，我们将讨论 DNA 何时、何地以及如何被降解以维持哺乳动物的体内平衡。