从星盘海星 Asteropsis carinifera 中分离得到的 Cariniferosides A-F 和其他甾体类大糖基化合物。

Cariniferosides A-F and other steroidal biglycosides from the starfish Asteropsis carinifera.

机构信息

Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.

出版信息

Steroids. 2011 Nov;76(12):1280-7. doi: 10.1016/j.steroids.2011.06.006. Epub 2011 Jul 7.

DOI:10.1016/j.steroids.2011.06.006

PMID:21763335

Abstract

Six new steroidal biglycosides, cariniferosides A-F (1-6), were isolated along with six previously known glycosides, 7-12, from the alcoholic extract of the starfish Asteropsis carinifera. The structures of 1-6 were determined by extensive NMR and ESIMS techniques. The isolated compounds did not show any apparent cytotoxicity in cancer cell lines HCT-116, RPMI-7951, and T-47D, but sulfated compounds 6, 11, and 12 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in a soft agar clonogenic assay.

摘要

从星状多棘海星 Asteropsis carinifera 的醇提物中分离得到了 6 个新的甾体大糖苷化合物 cariniferosides A-F（1-6）以及 6 个先前已知的糖苷化合物 7-12。通过广泛的 NMR 和 ESIMS 技术确定了 1-6 的结构。这些分离得到的化合物在 HCT-116、RPMI-7951 和 T-47D 癌细胞系中没有表现出明显的细胞毒性，但硫酸化化合物 6、11 和 12 在软琼脂集落形成实验中对 RPMI-7951 和 T-47D 细胞集落形成表现出显著的抑制作用。