Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, People's Republic of China.
J Nat Prod. 2010 Apr 23;73(4):590-7. doi: 10.1021/np9007188.
Ten new polyhydroxysteroidal glycosides, anthenosides B-K (2-11), were isolated from the ethanol extract of the starfish Anthenea chinensis. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The unprecedented carbohydrate chain 6-O-methyl-beta-d-galactofuranosyl-(1-->3)-(6-O-methyl-beta-d-galactofuranose) was present in all the compounds except compounds 10 and 11. Compounds 5, 7, a mixture of 8 and 9, and a mixture of 10 and 11 showed inhibitory activity against human tumor K-562 and BEL-7402 cells. Furthermore, the mixture of 10 and 11 also exhibited cytotoxicity against human tumor U87MG cells and promoted tubulin polymerization.
从中国海星中分离出的乙醇提取物中，分离得到了 10 种新的多羟基甾体糖苷，即安替诺斯苷 B-K（2-11）。通过广泛的光谱研究和化学证据阐明了它们的结构。除化合物 10 和 11 外，所有化合物都存在前所未有的碳水化合物链 6-O-甲基-β-d-半乳糖呋喃基-（1-->3）-（6-O-甲基-β-d-半乳糖呋喃糖）。化合物 5、7、8 和 9 的混合物以及化合物 10 和 11 的混合物对人肿瘤 K-562 和 BEL-7402 细胞表现出抑制活性。此外，化合物 10 和 11 的混合物还对人肿瘤 U87MG 细胞具有细胞毒性，并促进微管蛋白聚合。
