Department of Bioscience and Bioengineering, Dalian University of Technology, Dalian 116024, China.
J Biotechnol. 2012 Apr 30;158(4):176-83. doi: 10.1016/j.jbiotec.2011.06.038. Epub 2011 Jul 6.
Zinc is an essential element for the normal growth, metabolism and physiology of yeast. Besides acting as a cofactor for many enzymes, zinc is also required for the structural stability of zinc finger proteins, many of which exert important controls on cellular metabolic processes. Although the effect of zinc on ethanol fermentation has previously been reported, the role of zinc on cellular stress tolerance is not well studied. In this review, the latest progress regarding the important roles of zinc and zinc containing proteins in yeast metabolism and cellular function, especially the recent findings demonstrating the involvement of zinc finger proteins in cellular stress responses, are summarized, with the focus on stress tolerance of yeast in the context of fuel ethanol production. An in-depth understanding of the status of zinc in the reprogramming of yeast metabolic network is vital for the breeding of robust yeast strains for ethanol fermentation, as well as for improved production efficiency of yeast-based bioindustry.
锌是酵母正常生长、代谢和生理功能所必需的元素。除了作为许多酶的辅助因子外，锌还需要锌指蛋白的结构稳定性，其中许多蛋白对细胞代谢过程发挥着重要的控制作用。尽管锌对乙醇发酵的影响以前已有报道，但锌对细胞应激耐受性的作用尚未得到很好的研究。在这篇综述中，总结了锌和含锌蛋白在酵母代谢和细胞功能中的重要作用的最新进展，特别是最近发现的锌指蛋白参与细胞应激反应的研究结果，重点关注了在燃料乙醇生产背景下酵母的应激耐受性。深入了解锌在酵母代谢网络重编程中的状态对于培育用于乙醇发酵的健壮酵母菌株以及提高基于酵母的生物工业的生产效率至关重要。
