Department of Otolaryngology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Hear Res. 2011 Dec;282(1-2):289-302. doi: 10.1016/j.heares.2011.06.006. Epub 2011 Jul 3.
It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. Although neural stimulation can be achieved without direct contact of the radiation source and the tissue, the presence of fluids or bone between the target structure and the radiation source may lead to absorption or scattering of the radiation, which may limit the efficacy of INS. The present study demonstrates the neural structures in the radiation beam path that can be stimulated. Histological reconstructions and microCT of guinea pig cochleae stimulated with an infrared laser suggest that the orientation of the beam from the optical fiber determined the site of stimulation in the cochlea. Best frequencies of the INS-evoked neural responses obtained from the central nucleus of the inferior colliculus matched the histological sites in the spiral ganglion.
已经证明，INS 可用于刺激耳蜗中的螺旋神经节细胞。尽管可以在辐射源和组织不直接接触的情况下实现神经刺激，但在目标结构和辐射源之间存在液体或骨骼可能会导致辐射的吸收或散射，从而限制 INS 的疗效。本研究展示了可以刺激的辐射束路径中的神经结构。用红外激光刺激豚鼠耳蜗的组织学重建和 microCT 表明，光纤的光束方向决定了耳蜗中的刺激部位。从中耳下丘中枢核获得的 INS 诱发的神经反应的最佳频率与螺旋神经节的组织部位相匹配。
