Department of Dermatology and Division of Transplantation, Department of Surgery, Emory University, Atlanta, Georgia.
Department of Dermatology and Oncology, University of Rochester, Rochester, New York.
J Am Acad Dermatol. 2011 Aug;65(2):253-261. doi: 10.1016/j.jaad.2010.11.062.
Skin cancer is the most frequent malignancy in organ transplant recipients, 95% of which are nonmelanoma skin cancer, especially squamous cell and basal cell carcinomas. This paper also discusses the incidence of other tumors (eg, melanoma, Merkel cell carcinoma, and Kaposi sarcoma) that are also increased in organ transplant patients compared to the general population. Part I of this two-part series describes the latest data concerning the epidemiologic and pathogenic aspects of nonmelanoma skin cancer development in solid organ transplant recipients. This review also highlights the concept of "field cancerization," represented by extensive areas of actinic damage and epidermal dysplasia, which accounts for increased risk of aggressive skin cancer development in susceptible patients.
皮肤癌是器官移植受者中最常见的恶性肿瘤，其中 95%为非黑色素瘤皮肤癌，尤其是鳞状细胞癌和基底细胞癌。本文还讨论了其他肿瘤（如黑色素瘤、默克尔细胞癌和卡波西肉瘤）的发病率，这些肿瘤在器官移植患者中也比普通人群增加。本系列的两部分中的第一部分描述了有关实体器官移植受者中非黑色素瘤皮肤癌发展的流行病学和发病机制方面的最新数据。本综述还强调了“癌前病变”的概念，表现为广泛的光损伤和表皮发育不良区域，这增加了易感患者侵袭性皮肤癌发展的风险。
