Łącka Monika, Bernecka Paulina, Kondej Karolina, Jankau Jerzy
Department of Plastic Surgery, University Clinical Centre, Gdańsk, Poland.
Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Case Rep Dermatol. 2025 May 28;17(1):196-203. doi: 10.1159/000545836. eCollection 2025 Jan-Dec.
In 2023, solid organs were transplanted in 1,400 patients in Poland. Nonmelanoma skin cancer such as squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) is the most common malignancy in solid organ transplant recipients. Aims of the study were to present cases and discuss the possible course of skin cancer in patients after organ transplantation.
The study involved 3 patients after organ transplantation treated for skin cancer in the Department of Plastic Surgery of the University of Gdańsk in the years 2020-2023. Each patient is an example of a different course of the disease. In the case of patients treated with immunosuppression, a more aggressive course of the cancer should be considered, which may take various forms. One of the variants that we are dealing with in the first patient is the occurrence of multiple lesions, the co-occurrence of SCC and BCC, and frequent local recurrences. In the case of the second patient, we are dealing with a very aggressive course despite the early initiation of appropriate treatment. Another example of a different course is an atypical clinical picture that makes it difficult to make the correct diagnosis, which we observe in the third patient.
Our study demonstrates that due to the much higher morbidity, aggressive, rapid progression of the skin cancer disease, and unfavorable prognosis, population after transplantation requires a special oncological approach.
2023年，波兰有1400名患者接受了实体器官移植。非黑色素瘤皮肤癌，如鳞状细胞癌（SCC）或基底细胞癌（BCC），是实体器官移植受者中最常见的恶性肿瘤。本研究的目的是介绍病例并讨论器官移植后患者皮肤癌的可能病程。
该研究纳入了2020年至2023年期间在格但斯克大学整形外科接受皮肤癌治疗的3名器官移植后患者。每位患者都是不同病程的一个例子。对于接受免疫抑制治疗的患者，应考虑癌症病程更具侵袭性，可能呈现多种形式。我们在第一位患者中遇到的一种情况是出现多个病灶、SCC和BCC同时存在以及频繁的局部复发。在第二位患者中，尽管早期开始了适当治疗，但我们面对的是一个非常侵袭性的病程。不同病程的另一个例子是不典型的临床表现，这使得难以做出正确诊断，我们在第三位患者中观察到了这种情况。
我们的研究表明，由于皮肤癌发病率高得多、具有侵袭性、进展迅速且预后不佳，移植后人群需要特殊的肿瘤学治疗方法。
