发育生物学对多能干细胞研究的影响：成功与挑战。

The impact of developmental biology on pluripotent stem cell research: successes and challenges.

机构信息

Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto,Ontario, Canada.

出版信息

Dev Cell. 2011 Jul 19;21(1):20-3. doi: 10.1016/j.devcel.2011.06.010.

DOI:10.1016/j.devcel.2011.06.010

PMID:21763602

Abstract

Research on developmental pathways in model organisms provides key information on how to isolate, maintain, and differentiate human pluripotent stem cells. However, details of developmental pathways differ even across mammalian species. Full realization of the potential of stem cells will require more direct studies of human or primate developmental biology.

摘要

研究模式生物的发育途径为如何分离、维持和分化人类多能干细胞提供了关键信息。然而，即使在哺乳动物物种之间，发育途径的细节也存在差异。要充分发挥干细胞的潜力，还需要对人类或灵长类动物发育生物学进行更直接的研究。