Nishikawa Shin-ichi, Goldstein Robert A, Nierras Concepcion R
Laboratory for Stem Cell Biology, Center for Developmental Biology, RIKEN, Kobe, Hyogo, Japan.
Nat Rev Mol Cell Biol. 2008 Sep;9(9):725-9. doi: 10.1038/nrm2466.
Induced pluripotent stem (iPS) cells are human somatic cells that have been reprogrammed to a pluripotent state. There are several hurdles to be overcome before iPS cells can be considered as a potential patient-specific cell therapy, and it will be crucial to characterize the developmental potential of human iPS cell lines. As a research tool, iPS-cell technology provides opportunities to study normal development and to understand reprogramming. iPS cells can have an immediate impact as models for human diseases, including cancer
诱导多能干细胞（iPS细胞）是已被重编程为多能状态的人类体细胞。在iPS细胞被视为一种潜在的针对特定患者的细胞疗法之前，还有几个障碍需要克服，并且表征人类iPS细胞系的发育潜力至关重要。作为一种研究工具，iPS细胞技术为研究正常发育和理解重编程提供了机会。iPS细胞作为包括癌症在内的人类疾病模型可能会立即产生影响。
