Technical University of Dresden, DFG Center for Regenerative Therapies Dresden, c/o Max Planck Institute of Cell Biology and Genetics, Pfotenhauerstrasse 108, Dresden, Germany.
Dev Cell. 2011 Jul 19;21(1):172-85. doi: 10.1016/j.devcel.2011.06.016.
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies-from pluripotent stem cells to tissue-specific stem cells and dedifferentiation-are utilized for regeneration.
动物再生缺失部分的能力是生物学中一个引人注目的但尚未被充分理解的现象。数十年来，人们一直在寻找这些再生现象中新细胞的来源。最近在复杂组织中的细胞命运追踪方面的进展，为水螅、扁形动物、斑马鱼、非洲爪蟾和蝾螈的再生的细胞基础提供了新的认识。扁形动物利用成年多能干细胞来完成再生，而几种脊椎动物则利用来自不同组织的一系列谱系受限祖细胞。总之，一系列的细胞策略——从多能干细胞到组织特异性干细胞和去分化——被用于再生。
