Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
Cell. 2018 Oct 4;175(2):327-345. doi: 10.1016/j.cell.2018.09.021.
Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of dramatic feats of regeneration, which have been studied for over 2 centuries. Recent findings identify key cellular and molecular principles underlying these feats. A stem cell population (neoblasts) generates new cells and is comprised of pluripotent stem cells (cNeoblasts) and fate-specified cells (specialized neoblasts). Positional information is constitutively active and harbored primarily in muscle, where it acts to guide stem cell-mediated tissue turnover and regeneration. I describe here a model in which positional information and stem cells combine to enable regeneration.
再生是生物学的一大奥秘。水螅是一种能够进行惊人再生壮举的扁形动物，已经研究了两个多世纪。最近的发现确定了这些壮举背后的关键细胞和分子原理。一个干细胞群体（成体干细胞）产生新的细胞，由多能干细胞（cNeoblasts）和命运指定的细胞（专门的成体干细胞）组成。位置信息是持续活跃的，主要存在于肌肉中，在那里它起到指导干细胞介导的组织更新和再生的作用。我在这里描述了一个模型，其中位置信息和干细胞结合在一起，使再生成为可能。
