University of Twente, Department of Biomaterials Science and Technology, 7500 AE Enschede, The Netherlands.
Acta Biomater. 2011 Nov;7(11):3850-6. doi: 10.1016/j.actbio.2011.06.039. Epub 2011 Jun 27.
A photocrosslinkable poly(ε-caprolactone) (PCL)-based resin was developed and applied using stereolithography. No additional solvents were required during the structure preparation process. Three-armed PCL oligomers of varying molecular weights were synthesized, functionalized with methacrylic anhydride, and photocrosslinked, resulting in high gel content networks. Stereolithography was used to build designed porous scaffolds using the resin containing PCL macromer, Irgacure 369 photoinitiator, inhibitor and dye. A suitable resin viscosity was obtained by heating the resin during the curing process. The scaffolds precisely matched the computer-aided designs, with no observable material shrinkage. The average porosity was 70.5 ± 0.8%, and the average pore size was 465 μm. The pore network was highly interconnected. The photocrosslinkable, biodegradable PCL resin is well suited for the solvent-free fabrication of tissue engineering scaffolds by stereolithography.
一种光交联聚（ε-己内酯）（PCL）基树脂被开发出来，并通过立体光刻技术进行应用。在结构制备过程中不需要额外的溶剂。合成了不同分子量的三臂 PCL 低聚物，用甲基丙烯酰酐官能化，并进行光交联，得到高凝胶含量的网络。使用含有 PCL 大分子单体、Irgacure 369 光引发剂、抑制剂和染料的树脂，通过立体光刻技术构建设计的多孔支架。通过在固化过程中加热树脂，获得了合适的树脂粘度。支架与计算机辅助设计精确匹配，没有观察到明显的材料收缩。平均孔隙率为 70.5±0.8%，平均孔径为 465μm。孔网络高度互联。光交联可生物降解的 PCL 树脂非常适合通过立体光刻技术制备无溶剂的组织工程支架。
