Jansen Janine, Melchels Ferry P W, Grijpma Dirk W, Feijen Jan
Institute for Biomedical Technology (BMTI) and Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
Biomacromolecules. 2009 Feb 9;10(2):214-20. doi: 10.1021/bm801001r.
Polymer networks were prepared by photocross-linking fumaric acid monoethyl ester (FAME) functionalized, three-armed poly(D,L-lactide) oligomers using N-vinyl-2-pyrrolidone (NVP) as diluent and comonomer. The use of NVP together with FAME-functionalized oligomers resulted in copolymerization at high rates, and networks with gel contents in excess of 90% were obtained. The hydrophilicity of the poly(D,L-lactide) networks increases with increasing amounts of NVP, networks containing 50 wt % of NVP absorbed 40% of water. As the amount of NVP was increased from 30 to 50 wt %, the Young's modulus after equilibration in water decreased from 0.8 to 0.2 GPa, as opposed to an increase from 1.5 to 2.1 GPa in the dry state. Mouse preosteoblasts readily adhered and spread onto all prepared networks. Using stereolithography, porous structures with a well-defined gyroid architecture were prepared from these novel materials. This allows the preparation of tissue engineering scaffolds with optimized pore architecture and tunable material properties.
通过光交联富马酸单乙酯（FAME）功能化的三臂聚（D，L-丙交酯）低聚物制备聚合物网络，使用N-乙烯基-2-吡咯烷酮（NVP）作为稀释剂和共聚单体。NVP与FAME功能化低聚物一起使用导致高速率共聚，并获得凝胶含量超过90%的网络。聚（D，L-丙交酯）网络的亲水性随着NVP用量的增加而增加，含有50 wt% NVP的网络吸收40%的水。随着NVP用量从30 wt%增加到50 wt%，在水中平衡后的杨氏模量从0.8 GPa降至0.2 GPa，而在干燥状态下则从1.5 GPa增加到2.1 GPa。小鼠前成骨细胞很容易粘附并铺展在所有制备的网络上。使用立体光刻技术，由这些新型材料制备出具有明确类螺旋结构的多孔结构。这使得能够制备具有优化孔结构和可调材料性能的组织工程支架。
