Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, USA.
Trends Parasitol. 2011 Aug;27(8):345-54. doi: 10.1016/j.pt.2011.03.006. Epub 2011 Jul 19.
Genes reside in particular genomic contexts that can be mapped at many levels. Historically, 'genetic maps' were used primarily to locate genes. Recent technological advances in the determination of genome sequences have made the analysis and comparison of whole genomes possible and increasingly tractable. What do we see if we shift our focus from gene content (the 'inventory' of genes contained within a genome) to the composition and organization of a genome? This review examines what has been learned about the evolution of the apicomplexan genome as well as the significance and impact of genomic location on our understanding of the eukaryotic genome and parasite biology.
基因存在于特定的基因组环境中，可以在多个层面进行映射。从历史上看，“遗传图谱”主要用于定位基因。最近在确定基因组序列方面的技术进步使得对整个基因组的分析和比较成为可能，并且越来越具有可操作性。如果我们将注意力从基因含量（基因组中包含的基因“清单”）转移到基因组的组成和组织上，我们会看到什么？这篇综述考察了我们对顶复门基因组进化的了解，以及基因组位置对我们理解真核生物基因组和寄生虫生物学的意义和影响。
