Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
J Stroke Cerebrovasc Dis. 2013 Jan;22(1):55-7. doi: 10.1016/j.jstrokecerebrovasdis.2011.06.001. Epub 2011 Jul 18.
We studied the association of causes and stroke outcome of stroke in the young in Thailand.
A retrospective study was performed at Srinagarind Hospital, Khon Kaen University, Thailand. All patients under 45 years of age who were diagnosed with stroke between 1996 and 2010 and who had complete workups for causes of stroke in the young were enrolled. Stroke outcome was defined as favorable or nonfavorable at approximately 1 year of follow-up. If the patient had normal functional ability or mild disability but the patient was fully employed, the outcome was classified as favorable. Clinical features of strokes and the potential stroke risk factors were compared between the favorable and nonfavorable groups.
Eighty-five patients were enrolled. About half of patients were male (47 patients; 55.3%). The mean age (SD) was 35.9 (6.2) years. Three-fourths of male patients had a stroke after 30 years of age, while female patients developed stroke in all age ranges equally. More than half of patients (45 patients; 52.9%) had cardiac causes of stroke. Rheumatic mitral stenosis accounted for 68% (31 patients), and 45% (14 patients) had atrial fibrillation. There were 64 patients (79%) who had a favorable outcome. Cardiac causes, particularly mitral stenosis and alcohol intake, were significantly associated with a nonfavorable outcome.
Stroke in the young generally has a favorable outcome. Factors associated with a nonfavorable outcome of stroke in the young were cardiac abnormalities and alcohol intake. A prospective study to evaluate the association of causes and outcome is needed.
我们研究了泰国青年中风的病因和中风结局之间的关系。
这是一项在泰国孔敬大学诗琳通医院进行的回顾性研究。1996 年至 2010 年间，所有年龄在 45 岁以下、经全面检查明确病因的青年中风患者均纳入本研究。中风结局定义为约 1 年随访时的良好结局或不良结局。如果患者的功能能力正常或仅有轻度残疾，但患者仍全职工作，则结局被分类为良好。比较了两组间的中风临床特征和潜在的中风危险因素。
共纳入 85 例患者。约一半患者为男性（47 例，55.3%）。平均年龄（标准差）为 35.9（6.2）岁。四分之三的男性患者在 30 岁后发生中风，而女性患者则在各年龄段均有发病。超过一半的患者（45 例，52.9%）有心脏原因引起的中风。风湿性二尖瓣狭窄占 68%（31 例），45%（14 例）有房颤。64 例（79%）患者有良好结局。心脏原因，特别是二尖瓣狭窄和酒精摄入，与不良结局显著相关。
青年中风的总体结局良好。与青年中风不良结局相关的因素是心脏异常和酒精摄入。需要进行前瞻性研究以评估病因和结局之间的关系。
