Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Tuberculosis (Edinb). 2011 Nov;91(6):533-43. doi: 10.1016/j.tube.2011.06.005. Epub 2011 Jul 18.
About a third of the human population is estimated to be infected with Mycobacterium tuberculosis. The bacterium displays an excellent adaptability to survive within the host macrophages. As the reactive environment of macrophages is capable of inducing DNA damage, the ability of the pathogen to safeguard its DNA against the damage is of paramount significance for its survival within the host. Analysis of the genome sequence has provided important insights into the DNA repair machinery of the pathogen, and the studies on DNA repair in mycobacteria have gained momentum in the past few years. The studies have revealed considerable differences in the mycobacterial DNA repair machinery when compared with those of the other bacteria. This review article focuses especially on the aspects of base excision, and nucleotide excision repair pathways in mycobacteria.
据估计，大约有三分之一的人口感染了结核分枝杆菌。该细菌显示出极好的适应能力，能够在宿主巨噬细胞内存活。由于巨噬细胞的反应环境能够诱导 DNA 损伤，因此病原体保护其 DNA 免受损伤的能力对其在宿主内的生存至关重要。对基因组序列的分析为病原体的 DNA 修复机制提供了重要的见解，近年来，分枝杆菌中的 DNA 修复研究也取得了进展。研究表明，分枝杆菌的 DNA 修复机制与其他细菌有很大的不同。本文特别关注分枝杆菌中碱基切除和核苷酸切除修复途径的方面。
