IRiS：基因组尺度上的 ARG 网络构建。
IRiS: construction of ARG networks at genomic scales.
机构信息
Computational Biology Center, IBM T J Watson Research, Yorktown Heights, NY 10598, USA.
出版信息
Bioinformatics. 2011 Sep 1;27(17):2448-50. doi: 10.1093/bioinformatics/btr423. Epub 2011 Jul 15.
SUMMARY
Given a set of extant haplotypes IRiS first detects high confidence recombination events in their shared genealogy. Next using the local sequence topology defined by each detected event, it integrates these recombinations into an ancestral recombination graph. While the current system has been calibrated for human population data, it is easily extendible to other species as well.
AVAILABILITY
IRiS (Identification of Recombinations in Sequences) binary files are available for non-commercial use in both Linux and Microsoft Windows, 32 and 64 bit environments from https://researcher.ibm.com/researcher/view_project.php?id = 2303
CONTACT
摘要
给定一组现存的单倍型，IRiS 首先在它们的共享系统发育中检测到高置信度的重组事件。接下来，使用每个检测到的事件定义的局部序列拓扑结构，将这些重组事件整合到一个祖先重组图谱中。虽然当前的系统已经针对人类群体数据进行了校准，但它也可以很容易地扩展到其他物种。
可用性
IRiS（序列中重组的识别）二进制文件可在 Linux 和 Microsoft Windows、32 位和 64 位环境下非商业使用，可从 https://researcher.ibm.com/researcher/view_project.php?id=2303 获得。
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