Folkerts G, Janssen M, Nijkamp F P
State University of Utrecht, Faculty of Pharmacy, Department of Pharmacology, The Netherlands.
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):159S-161S. doi: 10.1111/j.1365-2125.1990.tb05493.x.
Guinea pigs were inoculated intra-tracheally with bovine parainfluenza type 3 virus (PI-3) to investigate whether airway hyperreactivity was associated with an increase in the number of broncho-alveolar cells. Two days after saline or PI-3 inoculation no difference in histamine reactivity of the isolated tracheal spirals was observed. The number of broncho-alveolar cells was also not changed. However, 4 days after PI-3 inoculation the histamine-induced contraction of the tracheal spirals was increased by 45% and the number of inflammatory cells in the airways by 150% as compared with the control group. In conclusion, PI-3 infection of the guinea pig respiratory airways induces tracheal hyperreactivity which is associated with an increase in broncho-alveolar cells.
将豚鼠经气管内接种牛副流感3型病毒（PI-3），以研究气道高反应性是否与支气管肺泡细胞数量增加有关。在接种生理盐水或PI-3两天后，未观察到分离出的气管螺旋条组胺反应性有差异。支气管肺泡细胞数量也未改变。然而，与对照组相比，接种PI-3四天后，组胺诱导的气管螺旋条收缩增加了45%，气道内炎性细胞数量增加了150%。总之，豚鼠呼吸道PI-3感染可诱发气管高反应性，这与支气管肺泡细胞数量增加有关。
