Department of Biology, Wilkes University, Wilkes-Barre, PA 18766, USA.
Mediators Inflamm. 2011;2011:296069. doi: 10.1155/2011/296069. Epub 2011 Jul 3.
Inflammation is a defensive process against tissue injury. Once this self-protective strategy is initiated, an effective resolution of the process is crucial to avoid major and unnecessary tissue damage. If the underlying event inducing inflammation is not addressed and homeostasis is not restored, this process can become chronic and lead to angiogenesis and carcinogenesis. Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. The effects of TSP-1 have been studied in many preclinical tumor models, and mimetic peptides are being tested in cancer clinical trials. However, the molecular mechanisms explaining its role in inflammatory processes are not well understood. This paper will discuss the role of TSP-1 in inflammation and its interaction with key receptors that may explain its functions in that process. Recent literature will be reviewed showing novel mechanisms by which this multifaceted protein could modulate the inflammatory process and impact its resolution.
炎症是一种针对组织损伤的防御过程。一旦启动了这种自我保护策略，有效地解决该过程对于避免重大和不必要的组织损伤至关重要。如果导致炎症的根本事件没有得到解决，并且体内平衡没有恢复，那么这个过程就会变成慢性的，并导致血管生成和癌变。血小板反应蛋白 1（TSP-1）是一种参与血管生成、癌症和炎症的基质细胞蛋白。在许多临床前肿瘤模型中研究了 TSP-1 的作用，并且模拟肽正在癌症临床试验中进行测试。然而，其在炎症过程中作用的分子机制尚不清楚。本文将讨论 TSP-1 在炎症中的作用及其与关键受体的相互作用，这些受体可能解释了它在该过程中的功能。将回顾最近的文献，展示这种多方面蛋白调节炎症过程并影响其解决的新机制。
