Li Z
Zhonghua Yi Xue Za Zhi. 1990 Oct;70(10):552-5, 38.
Activities of IL-1 produced by peripheral blood monocytes stimulated with lipopolysaccharide and IL-2 released by peripheral blood mononuclear cells induced by PHA, SWAP and SEA in vitro were detected in patients with various stages of schistosomiasis japonica. It was found that the activity of IL-1 was greatly increased and positively related to the body temperature, and high level of IL-2 was induced by SWAP and SEA in the group of acute schistosomiasis. The activity of IL-1 was significantly reduced in the groups of chronic and advanced schistosomiasis, especially in the latter group. The level of IL-2 induced by SWAP and SEA in the groups of chronic and advanced schistosomiasis was significantly lower than that in the group of acute schistosomiasis, but was much higher than that in the group of normal control. The level of IL-2 induced by SWAP and SEA in the cases of acute schistosomiasis was positively related to the activity of IL-1. The results indicate that the specific cellular immunity was increased in acute cases and decreased in chronic cases of schistosomiasis japonica. Both specific and nonspecific cellular immune responses were greatly reduced in cases of advanced schistosomiasis japonica. IL-1 and IL-2 may play an important role in the immunoregulation of schistosomiasis japonica.
检测了日本血吸虫病各期患者外周血单核细胞经脂多糖刺激产生的白细胞介素-1（IL-1）活性以及外周血单个核细胞经PHA、SWAP和SEA体外诱导释放的白细胞介素-2（IL-2）活性。结果发现，IL-1活性显著升高且与体温呈正相关，急性血吸虫病组中SWAP和SEA可诱导产生高水平的IL-2。慢性和晚期血吸虫病组中IL-1活性显著降低，尤其是晚期组。慢性和晚期血吸虫病组中SWAP和SEA诱导的IL-2水平显著低于急性血吸虫病组，但远高于正常对照组。急性血吸虫病病例中SWAP和SEA诱导的IL-2水平与IL-1活性呈正相关。结果表明，日本血吸虫病急性期特异性细胞免疫增强，慢性期降低。晚期日本血吸虫病病例中特异性和非特异性细胞免疫反应均显著降低。IL-1和IL-2可能在日本血吸虫病的免疫调节中起重要作用。
