Li Z J, Yang Q, Yang Y X, Zeng L L, Li S L, Dai J Z, Wang H C, Luo D D, Wang X H
Department of Infectious Diseases, Union Hospital, Tongji Medical University, Wuhan.
Chin Med J (Engl). 1993 Mar;106(3):175-8.
T cell subsets in peripheral blood were phenotyped in 56 patients with different stages of Schistosomiasis japonica, including 17 with acute, 14 with chronic and 25 with advanced infection. The activity of interleukin-1 (IL-1) produced by peripheral blood mononuclear cells (PBMC) induced by lipopolysaccharide (LPS) in vitro was simultaneously detected in these three groups of patients. It was found that the percentages of CD3+ (total T cell), CD4+ (helper/inducer T cell) and CD8+ (suppressor/cytotoxic T cell) T cell and the level of IL-1 were significantly increased in the group of acute Schistosomiasis japonica. In the groups of chronic and advanced Schistosomiasis japonica, the proportion of CD3+ T cell, the ratio of CD3+/CD4+ and the level of IL-1 were remarkably reduced, and the percentage of CD8+ T cell was increased. The rate of CD4+ T cell was obviously decreased in cases patients with advanced Schistosomiasis japonica. The percentage of CD4+ T cell was positively correlated to the level of IL-1 in the three groups of patients. These results indicate that T cell subsets and IL-1 may play an important role in the immunoregulation of Schistosomiasis japonica.
对56例不同阶段日本血吸虫病患者外周血中的T细胞亚群进行了表型分析，其中急性感染患者17例，慢性感染患者14例，晚期感染患者25例。同时检测了这三组患者外周血单个核细胞（PBMC）在体外脂多糖（LPS）诱导下产生白细胞介素-1（IL-1）的活性。结果发现，急性日本血吸虫病组中CD3+（总T细胞）、CD4+（辅助/诱导性T细胞）和CD8+（抑制/细胞毒性T细胞）T细胞的百分比以及IL-1水平显著升高。在慢性和晚期日本血吸虫病组中，CD3+T细胞比例、CD3+/CD4+比值以及IL-1水平显著降低，而CD8+T细胞百分比升高。晚期日本血吸虫病患者中CD4+T细胞比例明显降低。三组患者中CD4+T细胞百分比与IL-1水平呈正相关。这些结果表明，T细胞亚群和IL-1可能在日本血吸虫病的免疫调节中发挥重要作用。
