数学建模在医学研究中的作用：“无患者参与的研究？”
The role of mathematical modeling in medical research: "research without patients?".
作者信息
Chambers R B
机构信息
Outcomes Assessment Department, Alton Ochsner Medical Foundation, New Orleans, LA.
出版信息
Ochsner J. 2000 Oct;2(4):218-23.
Abstract
Computer controlled mathematical models of medical outcomes are commonly found in the current medical literature. What is less common is an understanding of the methods used to construct such models, leaving the consumers of medical research to accept the interpretations as presented. A basic knowledge of the concepts used to generate models will provide the clinician with the insight needed to critically evaluate medical literature based on mathematical models.
摘要
计算机控制的医学结果数学模型在当前医学文献中很常见。然而，对构建此类模型所使用方法的理解却不那么普遍，这使得医学研究的消费者只能接受所呈现的解释。了解用于生成模型的概念基础知识，将为临床医生提供基于数学模型批判性评估医学文献所需的洞察力。
相似文献
1
The role of mathematical modeling in medical research: "research without patients?".数学建模在医学研究中的作用：“无患者参与的研究？”
Ochsner J. 2000 Oct;2(4):218-23.
2
Mathematical modeling of cancer: the future of prognosis and treatment.癌症的数学建模：预后与治疗的未来
Clin Chim Acta. 2005 Jul 24;357(2):173-9. doi: 10.1016/j.cccn.2005.03.023.
3
SysBioMed report: advancing systems biology for medical applications.系统生物医学报告：推动系统生物学在医学应用中的发展。
IET Syst Biol. 2009 May;3(3):131-6. doi: 10.1049/iet-syb.2009.0005.
4
Avoiding and identifying errors in health technology assessment models: qualitative study and methodological review.避免和识别健康技术评估模型中的错误：定性研究和方法学综述。
Health Technol Assess. 2010 May;14(25):iii-iv, ix-xii, 1-107. doi: 10.3310/hta14250.
5
On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process.关于皮肤伤口愈合血管生成作为反应-传输过程的数学建模。
Front Physiol. 2015 Sep 30;6:262. doi: 10.3389/fphys.2015.00262. eCollection 2015.
6
Brain biomechanics: mathematical modeling of hydrocephalus.
Neurol Res. 2000 Jan;22(1):19-24. doi: 10.1080/01616412.2000.11741033.
7
A Mathematical Model of Human Papillomavirus (HPV) in the United States and its Impact on Cervical Cancer.美国人类乳头瘤病毒（HPV）数学模型及其对宫颈癌的影响
J Cancer. 2012;3:262-8. doi: 10.7150/jca.4161. Epub 2012 Jun 9.
8
Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics.动物健康领域的数学建模与模拟。第一部分：超越药代动力学
J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. doi: 10.1111/jvp.12278. Epub 2015 Nov 22.
9
The Connection Between Spatial and Mathematical Ability Across Development.跨发展阶段的空间能力与数学能力之间的联系。
Front Psychol. 2018 Jun 4;9:755. doi: 10.3389/fpsyg.2018.00755. eCollection 2018.
10
How to build a course in mathematical-biological modeling: content and processes for knowledge and skill.如何构建数学-生物学建模课程：知识和技能的内容和过程。
CBE Life Sci Educ. 2010 Fall;9(3):333-41. doi: 10.1187/cbe.10-03-0041.
引用本文的文献
1
Using Object-Oriented Simulation to Assess the Impact of the Frequency and Accuracy of Mobility Scoring on the Estimation of Epidemiological Parameters for Lameness in Dairy Herds.使用面向对象模拟评估移动性评分频率和准确性对奶牛群跛行流行病学参数估计的影响。
Animals (Basel). 2024 Jun 11;14(12):1760. doi: 10.3390/ani14121760.
2
Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways.植入物纹理与包膜挛缩：细胞和分子途径综述
Plast Reconstr Surg Glob Open. 2024 May 14;12(5):e5802. doi: 10.1097/GOX.0000000000005802. eCollection 2024 May.
3
Applications of Machine Learning (ML) and Mathematical Modeling (MM) in Healthcare with Special Focus on Cancer Prognosis and Anticancer Therapy: Current Status and Challenges.机器学习（ML）和数学建模（MM）在医疗保健中的应用，特别关注癌症预后和抗癌治疗：现状与挑战
Pharmaceutics. 2024 Feb 9;16(2):260. doi: 10.3390/pharmaceutics16020260.
4
Estimating functions for visual field progression in newly diagnosed exfoliation glaucoma patients in Sweden.在瑞典新诊断的剥脱性青光眼患者中，视野进展的估计函数。
Sci Rep. 2023 Nov 28;13(1):20979. doi: 10.1038/s41598-023-48336-6.
5
Accuracy of heart girth tapes in the estimation of weights of pre-weaned calves.心脏围带在预估断奶前犊牛体重方面的准确性。
Vet Rec Open. 2021 Aug 7;8(1):e16. doi: 10.1002/vro2.16. eCollection 2021 Dec.
6
Mathematical Modeling and Models for Optimal Decision-Making in Health Care.医疗保健中的数学建模与最优决策模型
Comput Math Methods Med. 2019 Aug 14;2019:2945021. doi: 10.1155/2019/2945021. eCollection 2019.
7
Comparing Strategies to Prevent Stroke and Ischemic Heart Disease in the Tunisian Population: Markov Modeling Approach Using a Comprehensive Sensitivity Analysis Algorithm.比较预防突尼斯人群中风和缺血性心脏病的策略：使用全面敏感性分析算法的马尔可夫建模方法。
Comput Math Methods Med. 2019 Jan 29;2019:2123079. doi: 10.1155/2019/2123079. eCollection 2019.
8
Inferring clonal structure in HTLV-1-infected individuals: towards bridging the gap between analysis and visualization.推断 HTLV-1 感染个体中的克隆结构：弥合分析与可视化之间的差距。
Hum Genomics. 2017 Jul 11;11(1):15. doi: 10.1186/s40246-017-0112-8.
9
Simulation of Trauma Incidents : Modelling the Evolution of Patients and Resources.创伤事件模拟：患者与资源演变的建模
J Med Syst. 2016 Nov;40(11):234. doi: 10.1007/s10916-016-0599-x. Epub 2016 Sep 21.
10
Recent publications by ochsner authors.奥克斯纳作者近期发表的作品。
Ochsner J. 2001 Apr;3(2):117-9.
本文引用的文献
1
Decision analysis for the surgeon.
World J Surg. 1999 Dec;23(12):1227-31. doi: 10.1007/s002689900653.
2
Bayesian analysis of prevalence with covariates using simulation-based techniques: applications to HIV screening.使用基于模拟的技术对带有协变量的患病率进行贝叶斯分析：在HIV筛查中的应用
Stat Med. 1999 Nov 30;18(22):3059-73. doi: 10.1002/(sici)1097-0258(19991130)18:22<3059::aid-sim247>3.0.co;2-o.
3
Decision analysis in critical care medicine.重症医学中的决策分析
Crit Care Clin. 1999 Jul;15(3):647-61, viii. doi: 10.1016/s0749-0704(05)70077-4.
4
A hierarchical Bayesian approach to age-specific back-calculation of cancer incidence rates.一种用于特定年龄癌症发病率反向计算的分层贝叶斯方法。
Stat Med. 1999 Apr 30;18(8):919-33. doi: 10.1002/(sici)1097-0258(19990430)18:8<919::aid-sim89>3.0.co;2-7.
5
Modelling risk from a disease in time and space.对疾病在时间和空间上的风险进行建模。
Stat Med. 1998 Sep 30;17(18):2045-2060. doi: 10.1002/(sici)1097-0258(19980930)17:18<2045::aid-sim943>3.0.co;2-p.
6
A two-state Markov chain for heterogeneous transitional data: a quasi-likelihood approach.用于异质过渡数据的两态马尔可夫链：一种拟似然方法。
Stat Med. 1998 Jul 15;17(13):1481-93. doi: 10.1002/(sici)1097-0258(19980715)17:13<1481::aid-sim858>3.0.co;2-h.
7
Modeling two-state disease processes with random effects.用随机效应模拟两态疾病过程。
Lifetime Data Anal. 1997;3(4):315-35. doi: 10.1023/a:1009650012039.
8
Minimum sample sizes for identifying chromosomal fragile sites from individuals: Monte Carlo estimation.
Hum Genet. 1997 Nov;101(1):109-12. doi: 10.1007/s004390050596.
9
Mathematical models in decision analysis.
Infect Control Hosp Epidemiol. 1997 Jan;18(1):65-73. doi: 10.1086/647503.
10
Risk-based environmental remediation: Bayesian Monte Carlo analysis and the expected value of sample information.基于风险的环境修复：贝叶斯蒙特卡洛分析与样本信息的期望值
Risk Anal. 1996 Feb;16(1):67-79. doi: 10.1111/j.1539-6924.1996.tb01437.x.
Zotero 插件