Smith Miles C, Boutell Chris, Davido David J
Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, 7047 Haworth Hall, Lawrence, KS 66045, USA.
Future Virol. 2011 Apr;6(4):421-429. doi: 10.2217/fvl.11.24.
Herpes simplex virus type 1 (HSV-1) has two distinct phases of its viral life cycle: lytic and latent. One viral immediate-early protein that is responsible for determining the balance between productive lytic replication and reactivation from latency is infected cell protein 0 (ICP0). ICP0 is a 775-amino acid really interesting new gene (RING)-finger-containing protein that possesses E3 ubiquitin ligase activity, which is required for ICP0 to activate HSV-1 gene expression, disrupt nuclear domain (ND) 10 structures, mediate the degradation of cellular proteins, and evade the host cell's intrinsic and innate antiviral defenses. This article examines our current understanding of ICP0's transactivating, E3 ubiquitin ligase, and antihost defense activities and their inter-relationships to one another. Lastly, we will discuss how these properties of ICP0 may be utilized as possible targets for HSV-1 antiviral therapies.
单纯疱疹病毒1型（HSV-1）的病毒生命周期有两个不同阶段：裂解期和潜伏期。一种负责决定增殖性裂解复制与潜伏期再激活之间平衡的病毒立即早期蛋白是感染细胞蛋白0（ICP0）。ICP0是一种含775个氨基酸的具有真正有趣新基因（RING）结构域的蛋白，具有E3泛素连接酶活性，这是ICP0激活HSV-1基因表达、破坏核结构域（ND）10结构、介导细胞蛋白降解以及逃避宿主细胞固有和天然抗病毒防御所必需的。本文探讨了我们目前对ICP0的反式激活、E3泛素连接酶和抗宿主防御活性及其相互关系的理解。最后，我们将讨论ICP0的这些特性如何可被用作HSV-1抗病毒治疗的可能靶点。
