酿酒酵母高丝氨酸激酶与原核生物高丝氨酸激酶同源。
Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases.
作者信息
Schultes N P, Ellington A D, Cherry J M, Szostak J W
机构信息
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.
出版信息
Gene. 1990 Dec 15;96(2):177-80. doi: 10.1016/0378-1119(90)90250-u.
PMID:2176637
Abstract
The Saccharomyces cerevisiae gene (THR1) encoding homoserine kinase (HK; EC 2.7.1.39) was cloned by complementation in yeast. Disruption of the THR1 gene results in threonine auxotrophy in yeast. Comparison of the amino acid sequences of yeast and bacterial HKs reveals substantial similarity.
摘要
通过在酵母中进行互补克隆了酿酒酵母中编码高丝氨酸激酶（HK；EC 2.7.1.39）的基因（THR1）。THR1基因的破坏导致酵母中苏氨酸营养缺陷。酵母和细菌高丝氨酸激酶的氨基酸序列比较显示出显著的相似性。
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