Laboratory of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Box 183, Dschang, Cameroon.
Chem Biodivers. 2011 Jul;8(7):1301-9. doi: 10.1002/cbdv.201000145.
Two new oleanane-type triterpenes named ivorengenin A (=3-oxo-2α,19α,24-trihydroxyolean-12-en-28-oic acid; 1) and ivorengenin B (=4-oxo-19α-hydroxy-3,24-dinor-2,4-secoolean-12-ene-2,28-dioic acid; 2), together with five known compounds, arjungenin, arjunic acid, betulinic acid, sericic acid, and oleanolic acid, were isolated from the barks of Terminalia ivorensis A. Chev. (Combretaceae). Their structures were established on the basis of 1D- and 2D-NMR data, and mass spectrometry. A biogenetic pathway to the formation of these compounds from sericic acid, isolated as the major compound from this plant, was proposed. The antioxidant activities of different compounds were investigated by means of the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays, and IC(50) values were calculated and compared with Trolox activity. Antiproliferative activities of the isolated compounds were also evaluated against MDA-MB-231, PC3, HCT116, and T98G human cancer cell lines, against which the compounds showed significant cytotoxic activities.
从榄仁树（Terminalia ivorensis A. Chev.）（使君子科）的树皮中分离得到了两个新的齐墩果烷型三萜，分别命名为ivorengenin A（=3-氧代-2α,19α,24-三羟基齐墩烷-12-烯-28-酸；1）和 ivorengenin B（=4-氧代-19α-羟基-3,24-降二萜-2,4-桥连齐墩-12-烯-2,28-二酸；2），以及 5 个已知化合物，arjungenin、arjunic acid、betulinic acid、丝氨酸和齐墩果酸。基于 1D 和 2D-NMR 数据和质谱，确定了它们的结构。提出了从丝氨酸（从该植物中分离得到的主要化合物）形成这些化合物的生物合成途径。通过 2,2-联氮双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）和 1,1-二苯基-2-苦基肼（DPPH）测定法研究了不同化合物的抗氧化活性，并计算了 IC（50）值并与 Trolox 活性进行了比较。还评估了分离得到的化合物对 MDA-MB-231、PC3、HCT116 和 T98G 人癌细胞系的抗增殖活性，这些化合物对这些癌细胞系表现出显著的细胞毒性。
