Mattout C, Mege J L, Capo C, Bongrand P, Fourel J
Faculté de Chirurgie Dentaire de Marseille.
J Parodontol. 1990 Nov;9(4):297-308.
Neutrophil function was assessed in family in which only one member suffered from Juvenile Periodontitis (JP). Directed mobility (fMet-Leu-Phe and zymosan-activated plasma) was decreased in all siblings without involving a seric inhibitor. Adhesion was studied by a new method which allows for the evaluation of both adhesive rate and binding strengths. The latter parameters were decreased in the parents neutrophils, but remained increased in a set of twin sisters. The specific receptor induced phagocytosis was altered in all members of the family (FC receptor: IgG-SCR, C3b and mannosylfucosyl receptor: zymosan). The superoxide generation in response to fMet-Leu-Phe was decreased while the PMA response was almost normal. These results suggest an overall abnormality of ligand-receptor interactions (C5a, fMet-Leu-Phe, Fc and C4b receptors), this defect seems to involve some membrane characteristics and underlines the absence of correlation between PMN deficiency and the clinical expression of J.P.
在一个仅有一名成员患青少年牙周炎（JP）的家庭中对中性粒细胞功能进行了评估。在所有未患该病的兄弟姐妹中，趋化运动（甲酰甲硫氨酰-亮氨酰-苯丙氨酸和酵母聚糖激活血浆）降低，且不存在血清抑制剂。采用一种新方法研究黏附作用，该方法可同时评估黏附率和结合强度。父母中性粒细胞中的后一项参数降低，但一对双胞胎姐妹的该项参数仍升高。该家族所有成员中特异性受体诱导的吞噬作用均发生改变（Fc受体：IgG-SCR、C3b和甘露糖基岩藻糖基受体：酵母聚糖）。对甲酰甲硫氨酰-亮氨酰-苯丙氨酸反应的超氧化物生成减少，而对佛波酯的反应几乎正常。这些结果表明配体-受体相互作用（C5a、甲酰甲硫氨酰-亮氨酰-苯丙氨酸、Fc和C4b受体）存在整体异常，这种缺陷似乎涉及一些膜特性，并强调了多形核中性粒细胞缺乏与青少年牙周炎临床表型之间缺乏相关性。
