Hara Y, Battey J, Gainer H
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Brain Res Mol Brain Res. 1990 Oct;8(4):319-24. doi: 10.1016/0169-328x(90)90045-f.
Mouse vasopressin (VP) and oxytocin (OT) genes were isolated from a genomic library and the nucleotide sequences of the two genes were determined. The two genes have similar three exon structures and a high similarity in the part of exon 1 encoding vasopressin or oxytocin nonapeptide and in exon 2 encoding the central core of neurophysin. They are linked together in a tail to tail orientation separated by a short 3.5 kb intergenic sequence and are transcribed from opposite strands. Both genes have a single transcription initiation site downstream from a TATA-like sequence and a single polyadenylated transcript of about 760 bp for the vasopressin mRNA and about 700 bp for the oxytocin mRNA.
从小鼠基因组文库中分离出血管加压素（VP）和催产素（OT）基因，并测定了这两个基因的核苷酸序列。这两个基因具有相似的三个外显子结构，在编码血管加压素或催产素九肽的外显子1部分以及编码神经垂体素中央核心的外显子2部分具有高度相似性。它们以尾对尾的方向连接在一起，中间间隔一个短的3.5 kb基因间序列，并从相反的链转录。两个基因在类似TATA序列下游都有一个单一的转录起始位点，血管加压素mRNA的单一多聚腺苷酸化转录本约为760 bp，催产素mRNA的约为700 bp。
